Atenolol, Nifedipine, and Their Combination in the Treatment of Systemic Hypertension (SH)
Material and Method of Work
We studied three therapies by Nifedipine (N), Atenolol (A) and their combination
(A+N) in 28 patients (15 men and 13 women) with mild to moderate SH. Diastolic
blood pressure (DBP) was between 90 to 114 mm Hg, mean value 108.3±2; systolic
blood pressure (SBP) was 159 to 200 mm Hg (mean value 184.0±5). Mean age was 48
years, with a range of 34
to 62. Mean weight was 73±3 kg; range 56 to 105.
Protocol
The study protocol consisted of a qualification phase, during which time
patients were considered for study inclusion by the use of criteria previously
described. This was 2 weeks (placebo washout phase).
After initial run-in placebo (P) period (2 weeks), patients were randomized
(double-blind) to Nifedipine 10 mg three times a day or Atenolol 100 mg once
daily. Each period lasted three weeks.
STUDY DESIGN
Results
After A and N monotherapy, supine, erect, and exercise BP were recorded. Only A
reduced erect systolic BP. A was more effective than N (p < 0.05). In 28
patients, changes in BP obtained by this treatment were:
P: (2.w.): 178±5/110±1. A: (3.w.): 150±7/98±4. N: (3.w.): 170±4/104±2.
In 12 patients with combined therapy 100 + 20 mg/day: A + N: (3.w.) BP was
140±7/90±3.
Atenolol was successful in 38 to 59% of pts, Nifedipine in 8 to 22%, while their
combination was successful in 75 to 90%.
Conclusion
ATENOLOL was successful in 38 to 59% of pts.
NIFEDIPINE was successful in 8 to 22% of pts.
COMBINATION in treatment of systemic hypertension with Atenolol and Nifedipine
was successful in 75 to 90% of pts.
Z. STAMENKOVIC, MD University Clinic of Cardiology,
Institute of Cardiovascular Diseases; Novi Sad, Yugoslavia
N. DRAGANIC, MD University Clinic of Cardiology, Institute of Cardiovascular
Diseases; Novi Sad, Yugoslavia
M. DRAGANIC-CECILIO University of Novi Sad, Medical Faculty; Novi Sad,
Yugoslavia (Medical Student, year IV)
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